In vitro and in vivo effects of tamoxifen against Echinococcus granulosus larval 1 stage 2 3 4

نویسندگان

  • María Celeste Nicolao
  • María Celina Elissondo
  • Guillermo M. Denegri
  • Andrea C. Cumino
چکیده

3 4 María Celeste Nicolao, María Celina Elissondo, Guillermo M. Denegri, Alejandra B. 5 Goya, Andrea C. Cumino # 6 7 1 Laboratorio de Zoonosis Parasitarias, Departamento de Biología, Facultad de Ciencias 8 Exactas y Naturales, Universidad Nacional de Mar del Plata (UNMdP), Funes 3350, Nivel Cero, 9 (7600) Mar del Plata, Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas 10 (CONICET), Argentina. 2 Departamento de Química, Facultad de Ciencias Exactas y Naturales, 11 Universidad Nacional de Mar del Plata (UNMdP), Funes 3350, Nivel 2, (7600) Mar del Plata, 12 Argentina. 3 Departamento de Toxinas Marinas, Laboratorio Regional Mar del Plata, Centro 13 Regional Buenos Aires Sur, Servicio Nacional de Sanidad y Calidad Agroalimentaria 14 (SENASA), Argentina. 15 16 Running Head: Tamoxifen clinical efficacy on Echinococcus granulosus 17 18 19 #Address correspondence to Andrea Cumino, [email protected] 20 21 22 AAC Accepts, published online ahead of print on 16 June 2014 Antimicrob. Agents Chemother. doi:10.1128/AAC.02113-13 Copyright © 2014, American Society for Microbiology. All Rights Reserved.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

BALB/c Mice Immunity to Hydatidosis Induced by In-vitro Reared Echinococcus granulosus Adult Worm Antigens

Background: Echinococcosis is a zoonotic parasitic disease caused by the larval stage of Echinococcus granulosus. Several native and recombinant antigens, derived from different stages of E. granulosus life cycle, have been used for vaccine trials. In vitro reared adult worms are good candidates for vaccination as they do not produce fertile egg/s and do not have any risk of contamination for r...

متن کامل

Metformin exhibits preventive and therapeutic efficacy against experimental cystic echinococcosis

Metformin (Met) is an anti-hyperglycemic and potential anti-cancer agent which may exert its anti-proliferative effects via the induction of energetic stress. In this study we investigated the in vitro and in vivo efficacy of Met against the larval stage of Echinococcus granulosus. Metformin showed significant dose- and time-dependent killing effects on in vitro cultured protoscoleces and metac...

متن کامل

In vitro effects of nitazoxanide on Echinococcus granulosus protoscoleces and metacestodes.

OBJECTIVES Infection of humans and domestic ruminants with the larval stage (metacestode) of Echinococcus granulosus results in cystic echinococcosis (CE). The metacestode causes a space-occupying lesion in visceral organs, most commonly in the liver. Benzimidazole carbamate derivatives, such as mebendazole and albendazole, are currently used for chemotherapeutic treatment of CE. In human patie...

متن کامل

In vitro metacestodicidal activities of genistein and other isoflavones against Echinococcus multilocularis and Echinococcus granulosus.

Echinococcus multilocularis and Echinococcus granulosus metacestode infections in humans cause alveolar echinococcosis and cystic echinococcosis, respectively, in which metacestode development in visceral organs often results in particular organ failure. Further, cystic hydatidosis in farm animals causes severe economic losses. Although benzimidazole derivatives such as mebendazole and albendaz...

متن کامل

Evaluation the scolicidal and cytotoxic effects of Froriepia subpinnataagainst protoscolex of Echinococcus granulosus in vitro

Background & Aim: Hydatidosis is one of the most important and prevalent parasitic diseases in Iran. Due to the fact that no definite and reliable treatment for this disease has been recorded so far, the aim of this study was to investigate the antiparasitic effect of Froriepia subpinnata (F. subpinnata) on the protoscolex stage of Echinococcus granulosus (E. granulosus) in vitro. Methods: F. ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2014